Entyvio Infusion Cost: Per-Dose Pricing, Subcutaneous Option, and Your Copay
{ if eq .Lang "zh" }{ else }{ end }In 2010 a drug like Entyvio didn’t exist for inflammatory bowel disease. Today a single infusion lists at $6,500 to $8,000, plus a separate facility fee — and you’ll get them every 8 weeks once you’re in maintenance. That contrast captures how far IBD treatment, and its price tag, has moved.
Entyvio is the brand name for vedolizumab, an anti-integrin biologic the FDA approved in 2014 for both Crohn’s disease and ulcerative colitis. It’s gut-selective, which many GI doctors like, but the billing is unusually layered because it’s traditionally an infusion drug split between two parts of your insurance.
Entyvio Cost Components
| Component | Typical Cost | Notes |
|---|---|---|
| Drug (per IV dose) | $6,500-$8,000 | List price, every 8 weeks in maintenance |
| Infusion facility fee | $500-$2,000 | Hospital outpatient costs more than clinic |
| Subcutaneous maintenance dose | Similar drug list price | No facility fee, self-injected |
| Commercial insurance + copay program | Under $100 | EntyvioConnect assistance |
| Medicare Part B (IV) | 20% coinsurance | Lower with supplement plan |
The drug itself is one line item; the place that infuses it is another. A hospital outpatient department almost always charges more for the same infusion than a freestanding clinic or your GI office’s infusion suite. That site-of-care difference can swing your total by thousands.
IV vs. the Subcutaneous Shot
In 2023 the FDA approved a subcutaneous maintenance version of Entyvio — a pen you inject at home every two weeks after the initial IV loading doses. The drug’s list price is in the same ballpark, but you eliminate the facility fee entirely.
Key Takeaway
What Insured Patients Actually Pay
Takeda’s EntyvioConnect program offers copay assistance for commercially insured patients, often bringing the per-dose cost under $100 or even to $0. Because IV Entyvio is frequently billed under your medical benefit rather than pharmacy, the way it’s processed differs from oral drugs — your coordinator can tell you which benefit applies.
Medicare is different. IV infusions usually fall under Part B with 20% coinsurance, which on a $7,000 drug is real money unless you have a Medigap or Advantage plan that covers it. Copay cards aren’t allowed for Medicare patients.
Where Entyvio Fits Among IBD Biologics
Entyvio is one of several biologic options, and your GI doctor’s choice depends on your disease and history. For the full lineup and how the prices compare, see our Crohn’s disease biologic medication cost guide. If your diagnosis is ulcerative colitis, the ulcerative colitis medication cost breakdown puts Entyvio in context with the alternatives.
Most patients try cheaper drugs first. The mesalamine medication cost guide covers the entry-level therapy insurers usually require before approving a biologic.
Prior Authorization and Infusion Logistics
Entyvio needs prior authorization, and insurers typically want documentation that conventional therapy failed. The loading schedule front-loads your visits: doses at weeks 0, 2, and 6, then every 8 weeks. Each IV visit ties up an infusion chair for 30 minutes plus monitoring, which is part of why the facility fee exists.
If the cost of all this GI care has you reeling, you’re not alone — the same pricing opacity shows up in procedures too. Our colonoscopy cost guide breaks down how facility fees inflate the bill in a strikingly similar way.
The Bottom Line
Entyvio’s per-infusion list price of $6,500 to $8,000 is only half the story — the facility fee and your insurance type decide the rest. Commercially insured patients with EntyvioConnect often pay under $100, while Medicare patients face 20% Part B coinsurance unless supplemented. The single biggest move you can make is controlling site of care and asking whether the subcutaneous pen lowers your total. Get a written estimate for both the drug and the facility before your first dose.
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